Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.

José Carlos RiveraBaraa NoueihedAnkush MadaanIsabelle LahaieJingyi PanJaques BelikSylvain Chemtob

Published in: Journal of neuroinflammation (2017)

Our findings reveal that BH4 is a key cofactor in regulating the expression of inflammatory and anti-angiogenic factors that play an important function in the maintenance of retinal microvasculature.

Keyphrases

diabetic retinopathy
oxidative stress
optic nerve
poor prognosis
optical coherence tomography
genome wide
single cell
binding protein
long non coding rna
dna methylation
gene expression