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The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions.

Angelos DimasAnna GoussiaAlexandra Papoudou-BaiAnastasia PolitiMinas PaschopoulosIordanis NavrozoglouAntonis MakrigiannakisThomas Vrekoussis
Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
Stress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development.
Keyphrases
  • poor prognosis
  • sentinel lymph node
  • amino acid
  • oxidative stress
  • cell proliferation
  • long non coding rna
  • signaling pathway
  • squamous cell
  • early stage
  • radiation therapy
  • lymph node
  • neoadjuvant chemotherapy