The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions.
Angelos DimasAnna GoussiaAlexandra Papoudou-BaiAnastasia PolitiMinas PaschopoulosIordanis NavrozoglouAntonis MakrigiannakisThomas VrekoussisPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
Stress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development.