Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α.
Alexis MathianPaul BreillatKarim DorghamPaul BastardCaroline CharreRaphael LhotePaul QuentricQuentin MoyonAlice-Andrée MariaggiSuzanne Mouries-MartinClara MellotFrançois AnnaJulien HarocheFleur Cohen-AubartDelphine SterlinNoël ZahrAdrian GervaisTom Le VoyerLucy BizienQuentin AmiotMicheline PhaMiguel HiéFrancois ChassetHans YsselMakoto MiyaraPierre CharneauPascale Ghillani-DalbinJean-Laurent CasanovaFlore RozenbergZahir AmouraGuy GorochovPublished in: Annals of the rheumatic diseases (2022)
The production of non-neutralising and neutralising anti-IFN-I antibodies in SLE is likely to be a consequence of SLE-associated high IFN-I serum levels, with a beneficial effect on disease activity, yet a greater viral risk. This finding reinforces the recommendations for vaccination against SARS-CoV-2 in SLE.