Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years.
Alex Martins GomesDhelfeson Willya Douglas-DE-OliveiraSérgio Diniz FerreiraTarcília Aparecida da SilvaLuís Otávio Miranda CotaFernando Oliveira CostaPublished in: Journal of applied oral science : revista FOB (2019)
The salivary concentration of TNF-α was increased in individuals with worse periodontal and peri-implant clinical condition and in those with a higher incidence of peri-implantitis, especially in the GNTP group. Longitudinal studies in larger populations are needed to confirm these findings and elucidate the role of this biomarker in peri-implant disease.