Novel hydrogels: are they poised to transform 3D cell-based assay systems in early drug discovery?
J Mark TreherneAline F MillerPublished in: Expert opinion on drug discovery (2023)
The emerging advantages of using these novel hydrogels for human 3D screening assays should enable the discovery of more cost-effective drugs, leading to improved patient benefits. Such a disruptive change could also reduce the considerable time lag from obtaining in vitro assay data to initiating clinical trials. There is now a sufficient body of data available in the literature to enable this ambition to become a reality by significantly improving the predictive validity of 3D cell-based assays in early drug discovery. Novel hydrogels are key to unlocking the full potential of these assay systems.
Keyphrases
- drug discovery
- high throughput
- single cell
- drug delivery
- clinical trial
- hyaluronic acid
- cell therapy
- extracellular matrix
- drug release
- electronic health record
- endothelial cells
- systematic review
- tissue engineering
- big data
- case report
- randomized controlled trial
- stem cells
- open label
- risk assessment
- machine learning
- phase ii
- human health
- drug induced