Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes: Secondary analyses of the DALI lifestyle randomized controlled trial.
Mireille Nicoline Maria van PoppelRosa CorcoyDavid HillDavid SimmonsLeire MendizabalMirella ZuluetaLaureano SimonGernot Desoyenull nullPublished in: The American journal of clinical nutrition (2021)
In women homozygous for the risk allele of MTNR1B rs10830962, GDM risk was increased and PA intervention might be more beneficial than HE intervention for reducing maternal insulin resistance, cord blood C-peptide and cord blood leptin.
Keyphrases
- cord blood
- randomized controlled trial
- insulin resistance
- metabolic syndrome
- pregnancy outcomes
- polycystic ovary syndrome
- study protocol
- physical activity
- cardiovascular disease
- weight loss
- birth weight
- adipose tissue
- type diabetes
- high fat diet
- pregnant women
- skeletal muscle
- body mass index
- systematic review
- preterm birth