Bee Venom Phospholipase A2 Ameliorates Atherosclerosis by Modulating Regulatory T Cells.
Geun-Hyung KangSujin LeeDa Bin ChoiDasom ShinJahee KimHyeJin YangHyunsu BaePublished in: Toxins (2020)
Atherosclerosis is a chronic inflammatory disease caused by lipids and calcareous accumulations in the vascular wall due to an inflammatory reaction. Recent reports have demonstrated that regulatory T (Treg) cells have an important role as a new treatment for atherosclerosis. This study suggests that bee venom phospholipase A2 (bvPLA2) may be a potential therapeutic agent in atherosclerosis by inducing Treg cells. We examined the effects of bvPLA2 on atherosclerosis using ApoE-/- and ApoE-/-/Foxp3DTR mice. In this study, bvPLA2 increased Treg cells, followed by a decrease in lipid accumulation in the aorta and aortic valve and the formation of foam cells. Importantly, the effect of bvPLA2 was found to depend on Treg cells. This study suggests that bvPLA2 can be a potential therapeutic agent for atherosclerosis.
Keyphrases
- induced apoptosis
- regulatory t cells
- aortic valve
- cell cycle arrest
- cardiovascular disease
- endoplasmic reticulum stress
- signaling pathway
- transcatheter aortic valve replacement
- type diabetes
- cell death
- left ventricular
- cell proliferation
- coronary artery
- transcription factor
- adipose tissue
- aortic stenosis
- fatty acid
- adverse drug