Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity.
Xue LiXing-Yu ChenBing-Ying FanQun YuJie LeiZhi-Gang XuZhong-Zhu ChenPublished in: Molecules (Basel, Switzerland) (2023)
An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC 50 value of 10.65 μM.
Keyphrases
- high efficiency
- cell cycle arrest
- visible light
- induced apoptosis
- room temperature
- papillary thyroid
- signaling pathway
- cell death
- randomized controlled trial
- hydrogen peroxide
- health risk
- human health
- electron transfer
- radiofrequency ablation
- nitric oxide
- oxidative stress
- climate change
- cell proliferation
- childhood cancer
- drinking water
- human immunodeficiency virus
- hiv testing
- hiv infected
- genetic diversity
- heavy metals