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Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes.

Cristina Astrid TentoriCaterina GregorioMarie RobinNico GagelmannCarmelo GurnariSomedeb BallJuan Carlos Caballero-BerrocalLuca LaninoSaverio D'AmicoMarta SpreaficoGiulia MaggioniErica TravaglinoElisabetta SautaManja MeggendorferLin-Pierre ZhaoAlessia Campagnanull nullVictor SavevskiArmando SantoroNajla Al AliDavid A SallmanFrancisco SoléGuillermo Garcia ManeroUlrich GermingNicolaus KrögerShahram KordastiValeria SantiniGuillermo F SanzWolfgang KernUwe PlatzbeckerMaria Diez CampeloJaroslaw P MaciejewskiLionel AdesPierre FenauxTorsten HaferlachAmer M ZeidanGastone C CastellaniRami S KomrokjiFrancesca IevaMatteo Giovanni Della Portanull null
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
These results provide evidence for the clinical relevance of including genomic features into the transplantation decision making process, allowing personalizing the hazards and effectiveness of HSCT in patients with MDS.
Keyphrases
  • allogeneic hematopoietic stem cell transplantation
  • decision making
  • acute myeloid leukemia
  • acute lymphoblastic leukemia
  • copy number
  • randomized controlled trial
  • systematic review
  • cell therapy
  • bone marrow