Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.

Denise TürkNina HankeSarah WolfSebastian FrechenThomas EissingThomas WendlMatthias SchwabThorsten Lehr

Published in: Clinical pharmacokinetics (2020)

Whole-body PBPK models of gemfibrozil, repaglinide, and pioglitazone have been built and qualified for DDI and DGI prediction. PBPK modeling is applicable to investigate complex interactions between multiple drugs and genetic polymorphisms.

Keyphrases

helicobacter pylori
drug induced
mycobacterium tuberculosis
adverse drug
genome wide
helicobacter pylori infection
dna methylation
transcription factor
electronic health record