Thorsten Lehr

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 56

Top Venues

Pharmaceutics

CPT: pharmacometrics & systems pharmacology

Clinical pharmacology and therapeutics

Clinical pharmacokinetics

Saarland University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Saarland University

Germany

Professor Clinical Pharmacy :: Clinical Pharmacy

Publications

Christina Schräpel, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr
A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT: pharmacometrics & systems pharmacology (2024)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Dominik Selzer, Robert Dallmann, Jesse Joachim Swen, Henk-Jan Guchelaar, Matthias Schwab, Thorsten Lehr
Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy. Clinical pharmacology and therapeutics (2024)
Christina Schräpel, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr
A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT: pharmacometrics & systems pharmacology 13 (7) (2024)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Dominik Selzer, Robert Dallmann, Jesse Joachim Swen, Henk-Jan Guchelaar, Matthias Schwab, Thorsten Lehr
Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy. Clinical pharmacology and therapeutics 115 (6) (2024)
Helena Leonie Hanae Loer, Christina Kovar, Simeon Rüdesheim, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT: pharmacometrics & systems pharmacology 13 (6) (2024)
Christina Schräpel, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr
A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT: pharmacometrics & systems pharmacology 13 (7) (2024)
Helena Leonie Hanae Loer, Christina Kovar, Simeon Rüdesheim, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT: pharmacometrics & systems pharmacology 13 (6) (2024)
Helena Leonie Hanae Loer, Christina Kovar, Simeon Rüdesheim, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT: pharmacometrics & systems pharmacology (2024)
Christina Schräpel, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr
A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT: pharmacometrics & systems pharmacology 13 (7) (2024)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Dominik Selzer, Robert Dallmann, Jesse Joachim Swen, Henk-Jan Guchelaar, Matthias Schwab, Thorsten Lehr
Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy. Clinical pharmacology and therapeutics (2024)
Helena Leonie Hanae Loer, Christina Kovar, Simeon Rüdesheim, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT: pharmacometrics & systems pharmacology 13 (6) (2024)
Denise Türk, Nina Scherer, Dominik Selzer, Christiane Dings, Nina Hanke, Robert Dallmann, Matthias Schwab, Peter Timmins, Valerie Nock, Thorsten Lehr
Significant impact of time-of-day variation on metformin pharmacokinetics. Diabetologia (2023)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli, Thorsten Lehr
A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2) (2023)
Tobias Rothoeft, Folke Brinkmann, Christoph Maier, Dominik Selzer, Christiane Dings, Anna Kuehn, Eva Möhler, Hanna Grote, Alexandra Nonnenmacher, Markus Wenning, Michael Zemlin, Ulf Richter, Thorsten Lehr, Thomas Lücke
Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany. Children (Basel, Switzerland) 10 (12) (2023)
Katharina Och, Amin T Turki, Katharina M Götz, Dominik Selzer, Christian Brossette, Stefan Theobald, Yvonne Braun, Norbert Graf, Jochen Rauch, Kerstin Rohm, Gabriele Weiler, Stephan Kiefer, Ulf Schwarz, Lisa Eisenberg, Nico Pfeifer, Matthias Ihle, Andrea Grandjean, Sonja Fix, Claudia Riede, Jürgen Rissland, Sigrun Smola, Dietrich W Beelen, Dominic Kaddu-Mulindwa, Jörg Bittenbring, Thorsten Lehr
A dynamic time-to-event model for prediction of acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Cancer medicine 13 (1) (2023)
Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, Dominik Selzer, Matthias Schwab, Donato Teutonico, Sebastian Frechen, Maaike van der Lee, Dirk Jan A R Moes, Jesse J Swen, Thorsten Lehr
Physiologically Based Pharmacokinetic Modeling of Tacrolimus for Food-Drug and CYP3A Drug-Drug-Gene Interaction Predictions. CPT: pharmacometrics & systems pharmacology (2023)
Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, Dominik Selzer, Matthias Schwab, Donato Teutonico, Sebastian Frechen, Maaike van der Lee, Dirk Jan A R Moes, Jesse J Swen, Thorsten Lehr
Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT: pharmacometrics & systems pharmacology (2023)
Tobias Rothoeft, Folke Brinkmann, Christoph Maier, Dominik Selzer, Christiane Dings, Anna Kuehn, Eva Möhler, Hanna Grote, Alexandra Nonnenmacher, Markus Wenning, Michael Zemlin, Ulf Richter, Thorsten Lehr, Thomas Lücke
Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany. Children (Basel, Switzerland) 10 (12) (2023)
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van der Lee, Dirk Jan A R Moes, Jesse J Swen, Matthias Schwab, Thorsten Lehr
Physiologically Based Pharmacokinetic Modeling of Quinidine to Establish a CYP3A4, P-gp and CYP2D6 Drug-Drug-Gene Interaction Network. CPT: pharmacometrics & systems pharmacology (2023)
Laura Maria Fuhr, Fatima Zahra Marok, Uwe Fuhr, Dominik Selzer, Thorsten Lehr
Physiologically based pharmacokinetic modeling of bergamottin and 6,7-dihydroxybergamottin to describe CYP3A4 mediated grapefruit-drug interactions. Clinical pharmacology and therapeutics (2023)
Katharina Och, Amin T Turki, Katharina M Götz, Dominik Selzer, Christian Brossette, Stefan Theobald, Yvonne Braun, Norbert Graf, Jochen Rauch, Kerstin Rohm, Gabriele Weiler, Stephan Kiefer, Ulf Schwarz, Lisa Eisenberg, Nico Pfeifer, Matthias Ihle, Andrea Grandjean, Sonja Fix, Claudia Riede, Jürgen Rissland, Sigrun Smola, Dietrich W Beelen, Dominic Kaddu-Mulindwa, Jörg Bittenbring, Thorsten Lehr
A dynamic time-to-event model for prediction of acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Cancer medicine (2023)
Katharina Och, Amin T Turki, Katharina M Götz, Dominik Selzer, Christian Brossette, Stefan Theobald, Yvonne Braun, Norbert Graf, Jochen Rauch, Kerstin Rohm, Gabriele Weiler, Stephan Kiefer, Ulf Schwarz, Lisa Eisenberg, Nico Pfeifer, Matthias Ihle, Andrea Grandjean, Sonja Fix, Claudia Riede, Jürgen Rissland, Sigrun Smola, Dietrich W Beelen, Dominic Kaddu-Mulindwa, Jörg Bittenbring, Thorsten Lehr
A dynamic time-to-event model for prediction of acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Cancer medicine (2023)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli, Thorsten Lehr
A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2) (2023)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli, Thorsten Lehr
A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2) (2023)
Katharina Och, Amin T Turki, Katharina M Götz, Dominik Selzer, Christian Brossette, Stefan Theobald, Yvonne Braun, Norbert Graf, Jochen Rauch, Kerstin Rohm, Gabriele Weiler, Stephan Kiefer, Ulf Schwarz, Lisa Eisenberg, Nico Pfeifer, Matthias Ihle, Andrea Grandjean, Sonja Fix, Claudia Riede, Jürgen Rissland, Sigrun Smola, Dietrich W Beelen, Dominic Kaddu-Mulindwa, Jörg Bittenbring, Thorsten Lehr
A dynamic time-to-event model for prediction of acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Cancer medicine (2023)
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli, Thorsten Lehr
A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2) (2023)
Christina Schräpel, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter, Matthias Schwab, Thorsten Lehr
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14 (12) (2022)
Christina Schräpel, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter, Matthias Schwab, Thorsten Lehr
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14 (12) (2022)
Lukas Kovar, Lena Wien, Dominik Selzer, Yvonne Kohl, Robert Bals, Thorsten Lehr
In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier. Pharmaceuticals (Basel, Switzerland) 15 (2) (2022)
Simeon Rüdesheim, Dominik Selzer, Thomas Mürdter, Svitlana Igel, Reinhold Kerb, Matthias Schwab, Thorsten Lehr
Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics 14 (8) (2022)
Christina Schräpel, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter, Matthias Schwab, Thorsten Lehr
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14 (12) (2022)
Laura Maria Fuhr, Fatima Zahra Marok, Maximilian Mees, Felix Mahfoud, Dominik Selzer, Thorsten Lehr
A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug-Drug Interaction Modeling. Pharmaceutics 14 (7) (2022)
Christiane Dings, Katharina Martha Götz, Katharina Och, Iryna Sihinevich, Quirin Werthner, Sigrun Smola, Marc Bliem, Felix Mahfoud, Thomas Volk, Sascha Kreuer, Jürgen Rissland, Dominik Selzer, Thorsten Lehr
Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts. Viruses 14 (10) (2022)
Denise Türk, Fabian Müller, Martin F Fromm, Dominik Selzer, Robert Dallmann, Thorsten Lehr
Renal Transporter-Mediated Drug-Biomarker Interactions of the Endogenous Substrates Creatinine and N 1 -Methylnicotinamide: A PBPK Modeling Approach. Clinical pharmacology and therapeutics 112 (3) (2022)
Christina Schräpel, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter, Matthias Schwab, Thorsten Lehr
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14 (12) (2022)
Frank W Paulus, Jens Joas, Ida Gerstner, Anna Kühn, Markus Wenning, Thomas Gehrke, Holger Burckhart, Ulf Richter, Alexandra Nonnenmacher, Michael Zemlin, Thomas Lücke, Folke Brinkmann, Tobias Rothoeft, Thorsten Lehr, Eva Möhler
Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic. Children (Basel, Switzerland) 9 (11) (2022)
Helena Leonie Hanae Loer, Denise Türk, José David Gómez-Mantilla, Dominik Selzer, Thorsten Lehr
Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Predictions. Pharmaceutics 14 (5) (2022)
Justine Hussong, Eva Möhler, Anna Kühn, Markus Wenning, Thomas Gehrke, Holger Burckhart, Ulf Richter, Alexandra Nonnenmacher, Michael Zemlin, Thomas Lücke, Folke Brinkmann, Tobias Rothoeft, Thorsten Lehr
Mental Health and Health-Related Quality of Life in German Adolescents after the Third Wave of the COVID-19 Pandemic. Children (Basel, Switzerland) 9 (6) (2022)
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klußmann, Thorsten Lehr
Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients. Pharmaceutics 14 (10) (2022)
Nina Hanke, Denise Türk, Dominik Selzer, Naoki Ishiguro, Thomas Ebner, Sabrina Wiebe, Fabian Müller, Peter Stopfer, Valerie Nock, Thorsten Lehr
A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals. Clinical pharmacokinetics 59 (11) (2021)
Lukas Kovar, Dominik Selzer, Hannah Britz, Neal Benowitz, Gideon St Helen, Yvonne Kohl, Robert Bals, Thorsten Lehr
Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies. Clinical pharmacokinetics 59 (9) (2021)
Laura Maria Fuhr, Nina Hanke, Bernd Meibohm, Thorsten Lehr
Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis. Clinical pharmacokinetics 59 (6) (2021)
Christina Schräpel, Lukas Kovar, Dominik Selzer, Ute Hofmann, Florian Tran, Walter Reinisch, Matthias Schwab, Thorsten Lehr
External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease. Pharmaceutics 13 (9) (2021)
Fatima Zahra Marok, Laura Maria Fuhr, Nina Hanke, Dominik Selzer, Thorsten Lehr
Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network. Pharmaceutics 13 (3) (2021)
Laura Maria Fuhr, Fatima Zahra Marok, Nina Hanke, Dominik Selzer, Thorsten Lehr
Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach. Pharmaceutics 13 (2) (2021)
Lukas Kovar, Andreas Weber, Michael Zemlin, Yvonne Kohl, Robert Bals, Bernd Meibohm, Dominik Selzer, Thorsten Lehr
Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients. Pharmaceutics 12 (10) (2020)
Jan-Georg Wojtyniak, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. Clinical pharmacology and therapeutics 109 (1) (2020)
Daniel Moj, Hugo Maas, André Schaeftlein, Nina Hanke, José David Gómez-Mantilla, Thorsten Lehr
A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Model of Dabigatran Etexilate, Dabigatran and Dabigatran Glucuronide in Healthy Adults and Renally Impaired Patients. Clinical pharmacokinetics 58 (12) (2020)
Denise Türk, Nina Hanke, Thorsten Lehr
A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions. Pharmaceutics 12 (11) (2020)
Simeon Rüdesheim, Jan-Georg Wojtyniak, Dominik Selzer, Nina Hanke, Felix Mahfoud, Matthias Schwab, Thorsten Lehr
Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions. Pharmaceutics 12 (12) (2020)
Lukas Kovar, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab, Thorsten Lehr
Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics 12 (6) (2020)
Denise Türk, Nina Hanke, Sarah Wolf, Sebastian Frechen, Thomas Eissing, Thomas Wendl, Matthias Schwab, Thorsten Lehr
Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clinical pharmacokinetics 58 (12) (2020)
Hannah Britz, Nina Hanke, Mitchell E Taub, Ting Wang, Bhagwat Prasad, Éric Fernandez, Peter Stopfer, Valerie Nock, Thorsten Lehr
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. Pharmaceutical research 37 (12) (2020)
Nina Hanke, Denise Türk, Dominik Selzer, Sabrina T Wiebe, Éric Fernandez, Peter Stopfer, Valerie Nock, Thorsten Lehr
A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies. Pharmaceutics 12 (6) (2020)
Anke-Katrin Volz, Jasper Dingemanse, Andreas Krause, Thorsten Lehr
Target-Mediated Population Pharmacokinetic Modeling of Endothelin Receptor Antagonists. Pharmaceutical research 37 (1) (2019)
Nina Hanke, Claudia Kunz, Meinolf Thiemann, Harald Fricke, Thorsten Lehr
Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients. Pharmaceutics 11 (4) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Thorsten Lehr