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Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.

Sarra SmatiArnaud PolizziAnne FougeratSandrine Ellero-SimatosYuna BlumYannick LippiMarion RégnierAlexia LaroyenneMarine HuilletMuhammad ArifCheng ZhangFrederic LasserreAlain MarrotTalal Al SaatiJingHong WanCaroline SommerClaire NayliesAurelie BatutCeline LukowiczTiffany FougerayBlandine TramuntPatricia DubotLorraine SmithJustine Bertrand-MichelNathalie HennuyerJean-Philippe PradereBart StaelsRemy BurcelinFrançoise LenfantJean-François ArnalThierry LevadeLaurence Gamet-PayrastreSandrine LagarrigueNicolas LoiseauSophie LotersztajnCatherine PosticWalter WahliChristophe BureauMaeva GuillaumeAdil MardinogluAlexandra MontagnerPierre GourdyHervé Guillou
Published in: Gut (2021)
NCT02390232.
Keyphrases
  • mouse model
  • genome wide
  • insulin resistance
  • emergency department
  • type diabetes
  • gene expression
  • adipose tissue
  • fatty acid
  • network analysis
  • electronic health record