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Monitoring of Circulating Tumor DNA Improves Early Relapse Detection After Axicabtagene Ciloleucel Infusion in Large B-Cell Lymphoma: Results of a Prospective Multi-Institutional Trial.

Matthew J FrankNasheed M HossainAli BukhariErin A DeanJay Y SpiegelGursharan K ClaireIlan KirschAllison P JacobChelsea D MullinsLik Wee LeeKatherine A KongJuliana K CraigCrystal L MackallAaron P RapoportMichael D JainSaurabh DahiyaFrederick L LockeDavid Bernard Miklos
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Noninvasive ctDNA assessments can risk stratify and predict outcomes of patients undergoing axi-cel for the treatment of large B-cell lymphoma. These results provide a rationale for designing ctDNA-based risk-adaptive chimeric antigen receptor T-cell clinical trials.
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