Multi-omics integration highlights the role of ubiquitination in endometriosis fibrosis.

Mengjie YangHong JiangXinyu DingLu ZhangHuaying ZhangJiahao ChenLijun LiXinqin HeZhixiong HuangQiong-Hua Chen

Published in: Journal of translational medicine (2024)

This study, employing multi-omics approaches, provides novel insights into endometriosis ubiquitination profiles and reveals aberrant expression of the E3 ubiquitin ligase TRIM33 in endometriotic tissues, emphasizing their critical involvement in fibrosis pathogenesis and potential therapeutic targets.

Keyphrases

single cell
poor prognosis
gene expression
long non coding rna
risk assessment