Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Xin ChenQian Lin SongZe Hong LiRui JiJia Yu WangChang GeZhuo Ni XiaoDuan Ying GuoJing YangPublished in: Oxidative medicine and cellular longevity (2022)
Changes to macrophage polarization affect the local microenvironment of the placenta, resulting in pathological pregnancy diseases such as recurrent spontaneous abortion (RSA). Macrophages are in close contact with trophoblasts during placental development, and trophoblast-derived cytokines are important regulators of macrophage polarization and function. Histone acetylation can affect the expression and secretion of cytokines, and ATP citrate lyase (ACLY) is an important factor that regulates histone acetylation. The aim of this study was to investigate the effect of ACLY expression differences in trophoblast on macrophage polarization and its mechanism. Our data demonstrate that ACLY level in placental villi of patients with RSA is decreased, which may lead to the inhibition of histone acetylation in trophoblasts, thereby reducing the secretion of IL-10. Reduced IL-10 secretion activates endoplasmic reticulum stress in macrophages, thus inhibiting their M2 polarization.
Keyphrases
- endoplasmic reticulum stress
- dna methylation
- poor prognosis
- histone deacetylase
- induced apoptosis
- stem cells
- binding protein
- signaling pathway
- transcription factor
- gene expression
- electronic health record
- long non coding rna
- big data
- machine learning
- pregnant women
- artificial intelligence
- preterm birth
- pregnancy outcomes
- deep learning