A Systematic Review of Naldemedine and Naloxegol for the Treatment of Opioid-Induced Constipation in Cancer Patients.

Ursula K BraunLeanne K JacksonMary Acelle G GarciaSyed N Imam

Published in: Pharmacy (Basel, Switzerland) (2024)

Naldemedine or naloxegol appeared safe and useful in the treatment of OIC in cancer patients and may improve their quality of life. Larger-scale randomized placebo-controlled studies of PAMORAs in cancer patients would strengthen existing evidence.

Keyphrases

placebo controlled
double blind
clinical trial
randomized controlled trial
squamous cell carcinoma
phase ii
pain management
oxidative stress
combination therapy
radiation therapy
high glucose
phase ii study