Role of microRNA-223 in the regulation of poly(ADP-ribose) polymerase in pediatric patients with Crohn's disease.

Nóra Judit BéresZoltán KissKatalin E MüllerÁron CsehApor Veres-SzékelyRita LippaiRita BenkőÁrpád BarthaSzabolcs HeiningerÁdám VannayErna SzikszGábor VeresEszter M Horváth

Published in: Scandinavian journal of gastroenterology (2018)

In our study, we showed that the expression of miR-223 is up-regulated and poly(ADP-ribosyl)ation is reduced in pediatric patients with CD. Moreover, we confirmed their opposite change in LPS treated epithelial cells, too. These data suggest that the hypofunctionality of PARP-1 may play a potential role in the pathomechanism of CD.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
dna damage
electronic health record
nk cells
transcription factor
long noncoding rna
dna repair
big data
binding protein
oxidative stress
machine learning
artificial intelligence
structural basis