Benefits and Risks of Clopidogrel vs. Aspirin Monotherapy after Recent Ischemic Stroke: A Systematic Review and Meta-Analysis.

Maurizio PaciaroniBirsen InceBo HuJiann-Shing JengKursad KutlukLi-Ping LiuMin LouVladimir ParfenovKa Sing Lawrence WongBabak ZamaniDara PaekJung Min HanMichael Del AguilaShalini Girotra

Published in: Cardiovascular therapeutics (2019)

The analysis showed lower risks of major adverse cardiovascular or cerebrovascular events, recurrent stroke, and bleeding events for clopidogrel monotherapy compared to aspirin. These findings support clinical benefit for single antiplatelet therapy with clopidogrel over aspirin for secondary prevention in patients with recent ischemic stroke.

Keyphrases

antiplatelet therapy
atrial fibrillation
percutaneous coronary intervention
acute coronary syndrome
combination therapy
human health
coronary artery disease
risk assessment
randomized controlled trial
emergency department
subarachnoid hemorrhage
study protocol