Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.

Sini SkarpOlli-Pekka KämäräinenGong-Hong WeiEveliina JakkulaIlkka KivirantaHeikki KrögerJuha AuvinenPetri LehenkariLeena Ala-KokkoMinna Männikkö

Published in: PloS one (2018)

The identified variants revealed novel candidate genes for OA. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to OA.

Keyphrases

genome wide
copy number
knee osteoarthritis
transcription factor
genome wide identification
poor prognosis
dna methylation
bioinformatics analysis
rheumatoid arthritis
single cell
genome wide analysis