FOXO1 regulates wound-healing responses in human gingival fibroblasts.
Leticia RojasNicolás TobarJavier EspinozaSusana RíosConstanza Eugenia MartínezJorge MartínezDana T GravesPatricio Cristian SmithPublished in: Journal of periodontal research (2024)
The present study indicates that FOXO1 plays an important role in the modulation of several wound-healing functions in gingival fibroblast. Moreover, our findings reveal an important regulatory role for FOXO1 on the differentiation of gingival myofibroblasts, the regulation of cell migration, and collagen contraction, all these functions being critical during tissue repair and fibrosis.