Pharmacokinetic changes of cefdinir and cefditoren and its molecular mechanisms in acute kidney injury in rats.

Hepeng WangPengyuan SunChangyuan WangQiang MengZhihao LiuXiaokui HuoHuijun SunXiaodong MaJinyong PengKexin Liu

Published in: The Journal of pharmacy and pharmacology (2018)

The molecular mechanism of decreased expression of Oat1 and Oat3 was achieved through activating p53, and then increasing the expression of Bax and Caspase-3 and down regulating Bcl-2 in AKI rats. On this basis, the cumulative urinary excretion of cefdinir was significantly decreased and the plasma concentration of cefdinir was remarkably increased in AKI rats. However, the pharmacokinetic changes of cefditoren were not observed. Accordingly, cephalosporin antibiotics such as cefditoren should be firstly selected for the treatment in patients with AKI in clinic.

Keyphrases

acute kidney injury
poor prognosis
liver failure
induced apoptosis
primary care
binding protein
long non coding rna
intensive care unit
oxidative stress
hepatitis b virus
combination therapy
gram negative