The Assessment of Major Histocompatibility Complex (MHC) Class-I Expression in Different Neuromuscular Diseases.
Maher KurdiAysha AlshareefAhmed K BamagaZahir T FadelMoafaq S AlrawailiSahar HakamyFawaz MohamedAhmad R AbuzinadahBassam M J AddasNadeem Shafique ButtPublished in: Degenerative neurological and neuromuscular disease (2021)
MHC class-I cannot be solely used as a biomarker to distinguish IIMs from non-IIMs. The presence of MHC class-I molecules in non-IIMs might be related to immunoproteasomes mechanism. Further studies, with different muscle proteins expression and genomic sequencing, must be conducted to understand the role of MHC Class-I in neuromuscular diseases.