Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice.
Driely BarreirosCarolina Maschietto PucinelliKatharina Morant Holanda de OliveiraFrancisco Wanderley Garcia de Paula E SilvaPaulo Nelson FilhoLéa Assed Bezerra da SilvaErika Calvano KüchlerRaquel Assed Bezerra da Silva SegatoPublished in: Journal of applied oral science : revista FOB (2018)
The expression of the RANK, RANKL, OPG, MyD88 and TLR2 proteins as well as the ratio Tnfrsf11/Tnfrsf11b (RANKL/OPG) increased with AP progression. There was also a moderate positive correlation between the expression Myd88-Tnfrsf11 and Tlr2-Myd88, suggesting the relevance of Tlr2-Myd88 in bone loss due to bacterial infection.