Altered expression of apoptosis-related genes in rheumatoid arthritis peripheral blood mononuclear cell and related miRNA regulation.

Hamidreza EbrahimianMaryam AkhtariMaassoumeh AkhlaghiElham FarhadiAhmadreza JamshidiGholam Hossein AlishiriMahdi MahmoudiMahmood Tavallaie

Published in: Immunity, inflammation and disease (2023)

All selected genes have downregulated expression in RA PBMCs which could be correlated with RA pathogenesis by regulating apoptosis, cell survival, inflammatory mediator production, and proliferation. Due to the correlation of miR-16-5p, miR-34a-5p, and miR-335-5p with TP53 and FOXO1 expression in RA PBMCs, they could be used as future therapeutic targets.

Keyphrases

rheumatoid arthritis
poor prognosis
peripheral blood
oxidative stress
disease activity
endoplasmic reticulum stress
ankylosing spondylitis
signaling pathway
binding protein
interstitial lung disease
cell cycle arrest
gene expression
systemic lupus erythematosus
cell therapy
idiopathic pulmonary fibrosis