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Response to RL-225Ac in prostate cancer: effect of prior treatment with RL-177Lu: a systematic review of the literature.

Judith Stangl-KremserAndres Ricaurte-FajardoKritika SubramanianJoseph R OsborneMichael SunScott TagawaNeil H Bander
Published in: The Prostate (2023)
225Ac-PSMA RLT is an experimental treatment for men with mCRPC. There is limited data available from high-quality trials but so far PSMA-targeted RLT has demonstrated a low morbidity profile. Our review revealed that there is a possible decrease in efficacy of targeted alpha-particle therapy if individuals previously were exposed to 177Lu-PSMA RLT. However, the level of evidence is low. The underlying mechanism by which 177Lu-PSMA RLT might trigger possible radioresistance as well as randomized controlled trials are required to establish the therapeutic efficacy and safety of 225-Ac-PSMA RLT in men refractory to 177Lu-PSMA RLT. This article is protected by copyright. All rights reserved.
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