Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease.
Lisa VermuntC SutphenE DicksD M de LeeuwR AllegriS B BermanDavid M CashJ P ChhatwalCruchaga CarlosG DayM EwersM FarlowN C FoxB GhettiN Graff-RadfordJ HassenstabMathias JuckerCeleste M KarchJ KuhleC LaskeJ LevinC L MastersE McDadeH MoriJ C MorrisR J PerrinO PreischePeter R SchofieldM Suárez-CalvetC XiongPhilip ScheltensCharlotte E TeunissenPieter Jelle VisserRandell J BatemanTammie L S BenzingerA M FaganBrian A GordonBetty M TijmsPublished in: medRxiv : the preprint server for health sciences (2023)
Abnormal levels of fluid markers for neuronal damage and inflammatory processes in CSF are associated with grey matter network disruptions.The strongest association was with NfL, suggesting that axonal loss may contribute to disrupted network organization as observed in AD.Tracking biomarker trajectories over the disease course, changes in CSF biomarkers generally precede changes in brain networks by several years.