Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.

Malgorzata CyrankaAnna VeprikEleanor J McKayNienke van LoonAmber ThijsseLuke CotterNisha HareAffan SaibudeenSwathi LingamElisabete PiresPierre LarraufieFrank ReimannFiona GribbleMichelle StewartElizabeth BentleyPamela LearJames McCullaghJames CantleyRoger D CoxHeidi de Wet

Published in: Obesity (Silver Spring, Md.) (2020)

ABCC5 protein expression levels are inversely related to fat mass and appear to play a role in the regulation of GLP-1 secretion from enteroendocrine cells.

Keyphrases

adipose tissue
induced apoptosis
fatty acid
cell cycle arrest
signaling pathway
pi k akt
drug induced