Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism.

Chantal BertrandJean-Philippe PradèreNancy GeoffreSimon DeleruyelleBernard MasriJean PersonnazSophie Le GonidecAurélie BatutKatie LoucheCédric MoroPhilippe ValetIsabelle Castan-Laurell

Published in: Endocrine (2018)

Altogether, these results suggest that systemic apelin treatment decreases steatosis in insulin resistant mice without directly targeting hepatocytes.

Keyphrases

type diabetes
high fat diet induced
metabolic syndrome
adipose tissue
insulin resistance
fatty acid
bariatric surgery