Expression of the Tim3-galectin-9 axis is altered in drug-induced maculopapular exanthema.
Ruben Fernandez-SantamaríaFrancisca PalomaresMaria SalasImmaculada DoñaGador BogasAdriana ArizaAlba Rodriguez-NogalesMaria C Plaza-SeronCristobalina MayorgaMaría José TorresTahia Diana FernandezPublished in: Allergy (2019)
This study showed the involvement of the Tim3-Gal9 axis in MPE. The reduced expression of Tim3 in Th1 cells together with the impaired expression of Gal9 in PBMCs and DCs appears to have a role in the development of the disease. The potential of Gal9 to suppress Th1 and enhance Treg proliferation makes it a promising tool for treating these reactions.