Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure.
Charbel GhariosMandy M T van LeentHelena L ChangShady AbohashemDavid O'ConnorMichael T OsborneCheuk Y TangAudrey E KaufmanPhilip M RobsonSarayu RamachandranClaudia CalcagnoVenkatesh ManiMaria Giovanna TrivieriAntonia V SeligowskiSharon DekelWillem J M MulderJames W MurroughLisa M ShinAhmed TawakolZahi Adel FayadPublished in: European heart journal (2024)
In this study of limited size, participants with PTSD did not have higher atherosclerotic inflammation than controls. Notably, impaired cortico-limbic interactions (higher amygdala relative to vmPFC activity or disruption of their intercommunication) associated with carotid atherosclerotic burden. Larger studies are needed to refine these findings.