Functional megalin is expressed in renal cysts in a mouse model of adult polycystic kidney disease.

Marlene L NielsenMia C MundtDorte L LildballeMaria Rasmussen Lone SundeVicente E TorresPeter C HarrisHenrik Birn

Published in: Clinical kidney journal (2021)

Megalin-expressing cysts were observed at all ages, but the proportion decreased with age, possibly due to a switch in tubular origin, a merging of cysts of different tubular origin and/or a change in the expression pattern of cyst lining cells. Megalin expressed in cysts was functional, suggesting that megalin-mediated endocytosis is a potential mechanism for drug targeting in ADPKD if initiated early in the disease.

Keyphrases

polycystic kidney disease
mouse model
induced apoptosis
poor prognosis
cell cycle arrest
emergency department
high glucose
cancer therapy
cell death
cell proliferation
signaling pathway
risk assessment
binding protein
endothelial cells