Anti-Inflammatory Effects of Zinc Oxide and Berberine in Rats with Dextran Sulfate Sodium (DSS)-Induced Colitis.
Seon-Hyoung KimRangyeon LeeJang-Won YoonHee-Tae CheongChang-Six RaKi-Jong RheeJeongho ParkBae-Dong JungPublished in: Animals : an open access journal from MDPI (2024)
Zinc oxide (ZnO) is frequently used in high concentrations to prevent diarrhea in weaning pigs. However, it can produce environmental pollution, because it is not absorbed by the intestines and is excreted in the feces. In studies to identify an alternative substance to ZnO, we used a model of colitis induced by dextran sulfate sodium (DSS) in rats to compare the anti-inflammatory effects of berberine with ZnO. DSS-treated rats displayed weight loss, shortening of the colon, increased fecal water content, and an increase in the disease activity index (DAI). In contrast, DSS + ZnO- and DSS + berberine-treated rats exhibited reduced colon shortening, decreased fecal water content, and a decrease in the DAI. Histological analysis revealed that both ZnO and berberine treatment reduced epithelial cell damage, crypt destruction, and infiltration of inflammatory cells. Moreover, the liver damage index was not significantly different between ZnO and berberine-treated rats. This study indicated that both ZnO and berberine can improve DSS-induced colitis in rats and suggests berberine as an alternative treatment to ZnO that would not cause environmental pollution.
Keyphrases
- room temperature
- quantum dots
- reduced graphene oxide
- disease activity
- visible light
- weight loss
- rheumatoid arthritis
- risk assessment
- heavy metals
- systemic lupus erythematosus
- human health
- magnetic resonance imaging
- type diabetes
- magnetic resonance
- light emitting
- bariatric surgery
- induced apoptosis
- rheumatoid arthritis patients
- newly diagnosed
- gold nanoparticles
- anti inflammatory
- computed tomography
- ankylosing spondylitis
- drinking water
- combination therapy
- obese patients
- gastric bypass
- endoplasmic reticulum stress
- roux en y gastric bypass