Low Expression of the Androgen-Induced Tumor Suppressor Gene PLZF and Lethal Prostate Cancer.

Konrad H StopsackTravis GerkeSvitlana TyekuchevaYing Z MazzuGwo-Shu Mary LeeGoutam ChakrabortyWassim AbidaLorelei A MucciPhilip W Kantoff

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2019)

Suppression of PLZF as a consequence of androgen deprivation may be undesirable. PLZF should be tested as a predictive marker for resistance to androgen deprivation therapy.

Keyphrases

prostate cancer
poor prognosis
radical prostatectomy
high glucose
diabetic rats
copy number
genome wide
stem cells
oxidative stress
genome wide identification