TSPO expression in a Zika virus murine infection model as an imaging target for acute infection-induced neuroinflammation.
Carla Bianca Luena VictorioRasha MsallamWisna NoveraJoanne OngTham Jing YangArun GanasarajahJenny LowSatoru WatanabeAnn-Marie ChackoPublished in: European journal of nuclear medicine and molecular imaging (2022)
F]FEPPA uptake can be a surrogate marker for ZIKV disease and may be a potential PET imaging marker for ZIKV-induced neuroinflammation. Future TSPO-PET/SPECT studies on viral neuroinflammation and related encephalitis should assess the contribution of immune cells on TSPO expression and employ appropriate image correction methods to subtract blood pool activity.
Keyphrases
- pet imaging
- zika virus
- dengue virus
- poor prognosis
- lipopolysaccharide induced
- drug induced
- traumatic brain injury
- positron emission tomography
- lps induced
- high glucose
- diabetic rats
- aedes aegypti
- cognitive impairment
- cerebral ischemia
- pet ct
- liver failure
- computed tomography
- sars cov
- inflammatory response
- oxidative stress
- blood brain barrier
- intensive care unit
- current status
- acute respiratory distress syndrome
- photodynamic therapy
- risk assessment
- case control
- mechanical ventilation
- fluorescence imaging