Systematic review: efficacy of escalated maintenance anti-tumour necrosis factor therapy in Crohn's disease.
Vandita Y MattooChamara BasnayakeWilliam R ConnellNik Sheng DingMichael A KammMark LustOla NiewiadomskiAlexander ThompsonEmily K WrightPublished in: Alimentary pharmacology & therapeutics (2021)
Empiric escalation of maintenance anti-TNF therapy can recapture clinical response in a majority of patients with secondary loss of response to standard maintenance doses. Proactive optimisation of maintenance dosing might prolong time to loss of response in some patients.
Keyphrases
- systematic review
- end stage renal disease
- ejection fraction
- chronic kidney disease
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- meta analyses
- clinical trial
- bone marrow
- patient reported outcomes
- mesenchymal stem cells
- patient reported
- replacement therapy
- smoking cessation
- urinary tract infection