Differential roles of the Wip1-p38-p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas.

Chenyang XuTakeo MinaguchiNan QiKaoru FujiedaAsami SutoHiroya ItagakiAyumi ShikamaNobutaka TasakaAzusa AkiyamaSari NakaoHiroyuki OchiToyomi Satoh

Published in: World journal of surgical oncology (2022)

Wip1 appears to play a crucial role for the prognosis of OCCC through chemoresistance specifically in the advanced stages, implicating that Wip1 possibly serves as a reasonable therapeutic target for improving chemoresistance and poor prognosis of advanced-stage OCCC.

Keyphrases

poor prognosis
dna damage response
long non coding rna
clear cell
dna repair
oxidative stress