Clinical activity of transforming growth factor-β inhibitor vactosertib in combination with imatinib in desmoid tumors: a multicenter phase Ib/II study.

Jin-Hee Ahn Jeeyun Lee Changhee Park Seung-Hoon Beom Seung Hyun Kim Young Han Lee Kum-Hee Yun Jeong Eun Kim Woo-Yeol Baek Yoon Dae Han Sang-Kyum Kim Hyang Joo Ryu Inkyung Jung JooHee Lee Hong In Yoon Hyo Song Kim

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Vactosertib and imatinib combination was well-tolerated, with promising clinical activity in patients with progressive, locally advanced desmoid tumors. This is the first study investigating a novel target agent, a TGF-β inhibitor, in this rare and difficult-to-treat desmoid tumor.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
locally advanced
multiple sclerosis
rectal cancer
clinical trial
cross sectional
lymph node