Gene-Environment Interactions for Cardiovascular Disease.
Jaana A HartialaJames R HilserSubarna BiswasAldons J LusisHooman AllayeePublished in: Current atherosclerosis reports (2021)
Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, such as physical activity, air pollution, diet, and sex. The establishment of large consortia and population-based cohorts, in combination with new computational tools and mouse genetics platforms, can potentially overcome some of the limitations that have hindered human GxE interaction studies and reveal additional association signals for CVD-related traits. The identification of novel GxE interactions is likely to provide a better understanding of the pathogenesis and genetic liability of CVD, with significant implications for healthy lifestyles and therapeutic strategies.
Keyphrases
- coronary artery disease
- genome wide
- air pollution
- physical activity
- cardiovascular disease
- risk factors
- endothelial cells
- copy number
- dna methylation
- particulate matter
- type diabetes
- coronary artery bypass grafting
- heart failure
- smoking cessation
- left ventricular
- depressive symptoms
- cystic fibrosis
- sleep quality
- case control
- acute coronary syndrome
- pluripotent stem cells
- aortic valve
- transcatheter aortic valve replacement
- atrial fibrillation
- cardiovascular risk factors