Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
Young Min LeeSeok Hyun KimMinseok S KimDae Cheol KimEun Hee LeeJu Suk LeeSung-Hun LeeYoung Zoon KimPublished in: Cancers (2020)
The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.
Keyphrases
- epithelial mesenchymal transition
- poor prognosis
- dna methylation
- long non coding rna
- white matter
- gene expression
- long noncoding rna
- acute myeloid leukemia
- papillary thyroid
- signaling pathway
- cerebral ischemia
- transcription factor
- amino acid
- squamous cell carcinoma
- brain injury
- subarachnoid hemorrhage
- lymph node metastasis
- childhood cancer