Differences of RUNX2 gene promoter methylation and transcription level in ankylosing spondylitis.
Feier WangYuting ChenJiangping KongShanshan XuShengqian XuZongwen ShuaiGuoqi CaiFa-Ming PanPublished in: International journal of rheumatic diseases (2023)
The RUNX2 gene promoter was hypomethylated in AS patients. Meanwhile, the qRT-PCR verified the up-regulated expression on the transcription level, suggesting the abnormal methylation of RUNX2 contributes to the pathogenesis of AS.
Keyphrases
- transcription factor
- ankylosing spondylitis
- genome wide identification
- genome wide
- dna methylation
- end stage renal disease
- copy number
- newly diagnosed
- ejection fraction
- chronic kidney disease
- poor prognosis
- gene expression
- rheumatoid arthritis
- peritoneal dialysis
- prognostic factors
- binding protein
- long non coding rna
- systemic lupus erythematosus