Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma.
Lijie ZhaiApril BellErik LadomerskyKristen L LauingLakshmi BolluBrenda NguyenMatthew GenetMiri KimPeiwen ChenXinlei MiJennifer D WuMatthew J SchipmaBrian WrayJohn GriffithsRichard D UnwinSimon J ClarkRajesh AcharyaRiyue BaoCraig HorbinskiRimas V LukasGary E SchiltzDerek A WainwrightPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our study reveals a nonmetabolic IDO-mediated enhancement of CFH expression and provides a new therapeutic target for patients with GBM.