Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.

Kang Ho KimSungwoo ChoiYing ZhouEun Young KimJae Man LeePradip K SahaSayeepriyadarshini AnakkDavid D Moore

Published in: Hepatology (Baltimore, Md.) (2017)

Combined deletion of the hepatic FXR/SHP axis improves glucose/fatty acid homeostasis in aged mice, reversing the aging phenotype of body weight gain, increased adiposity, and glucose/insulin tolerance, suggesting a central role of this axis in whole-body energy homeostasis. (Hepatology 2017;66:498-509).

Keyphrases

weight gain
fatty acid
blood glucose
body mass index
birth weight
high fat diet induced
type diabetes
insulin resistance
glycemic control
adipose tissue