Dynamic Changes of Post-Radiotherapy Plasma Epstein-Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer.

Edwin Pun HuiBrigette B Y MaWai Kei Jacky LamK C Allen ChanFrankie MoQi-Yong Hemis Ai Ann D King Chi Hang Wong Kenneth C W WongDaisy C M LamMacy TongDarren M C PoonLeung LiThomas K H LauKwan Hung WongYuk Ming Dennis Lo Anthony T C Chan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Patients with NPC with detectable post-radiotherapy pEBV DNA who experienced subsequent pEBV DNA clearance had superior survival comparable with patients with initially undetectable post-radiotherapy pEBV DNA. Post-radiotherapy pEBV DNA clearance may serve as an early surrogate endpoint for long-term survival in NPC.

Keyphrases

circulating tumor
cell free
early stage
epstein barr virus
single molecule
locally advanced
radiation therapy
radiation induced
diffuse large b cell lymphoma