YAP-induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer.

Stefan ThomannSofia M E WeilerTeng WeiCarsten StichtCarolina De La TorreMarcell TóthFabian RoseYingyue TangThomas RitzClaudia BallHanno GlimmEduard RyschichPeter SchirmacherKai Breuhahn

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

In conclusion, YAP/TEAD4-regulated Ccl2 associates with perivascular recruitment of unpolarized Mɸimm and may contribute to a proangiogenic microenvironment in liver cancer.

Keyphrases

liver injury
drug induced
liver fibrosis
poor prognosis
high glucose
diabetic rats
adipose tissue
transcription factor
oxidative stress
endothelial cells
long non coding rna