Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways.

Wenxue HuangYalin ZhanYunfei ZhengYe HanWenjie HuJianxia Hou

Published in: Clinical science (London, England : 1979) (2019)

Ferritin is up-regulated by inflammation and exhibits cytokine-like activity in HPDLCs inducing a signaling cascade that promotes expression of pro-inflammatory cytokines associated with periodontitis.

Keyphrases

poor prognosis
oxidative stress
induced apoptosis
binding protein
endothelial cells
signaling pathway
cell cycle arrest
cell proliferation
long non coding rna
cell death
anti inflammatory
iron deficiency