[Continuous positive airway pressure therapy affects the recurrence of atrial fibrillation in patients with obstructive sleep apnea: a systematic review and meta-analysis].
Y X WangJ M LuoR HuangY XiaoPublished in: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (2023)
Objective: A higher incidence of atrial fibrillation is associated with obstructive sleep apnea. The effects of continuous positive airway pressure on atrial fibrillation have been studied in observational studies and randomized controlled trials. We therefore conducted this meta-analysis to assess the effect of continuous positive airway pressure on the recurrence of atrial fibrillation after radiofrequency ablation. Methods: A comprehensive search was conducted in Pubmed, Embase, Cochrane, Web of Science, Wanfang Data and CNKI databases from inception to October 2022. We included cohort studies and randomized controlled trials containing atrial fibrillation situation after catheter ablation with and without continuous positive airway pressure therapy. The random effects model was used to assess odds ratios ( OR ) and confidence intervals ( CI ). I 2 was used to assess the heterogeneity. Results: Eight studies with a total of 1 395 patients with obstructive sleep apnea met the inclusion criteria. Continuous positive airway pressure therapy decreased atrial fibrillation recurrence by 61% ( OR =0.392, 95% CI : 0.267-0.576, I 2 =37.6%). Subgroup analysis showed that the protective effect was more significant in groups with more hypertension patients ( OR= 0.272 vs . 0.550, 95% CI : 0.165-0.449 vs . 0.329-0.922). Conclusions: Continuous positive airway pressure therapy reduces the recurrence rate of atrial fibrillation. Patients with hypertension are more likely to benefit from it.
Keyphrases
- positive airway pressure
- obstructive sleep apnea
- atrial fibrillation
- catheter ablation
- sleep apnea
- left atrial
- left atrial appendage
- oral anticoagulants
- direct oral anticoagulants
- randomized controlled trial
- systematic review
- heart failure
- blood pressure
- radiofrequency ablation
- percutaneous coronary intervention
- free survival
- risk factors
- newly diagnosed
- meta analyses
- acute coronary syndrome
- bone marrow
- machine learning
- artificial intelligence
- venous thromboembolism
- prognostic factors
- clinical trial
- ejection fraction
- coronary artery disease
- cell therapy
- data analysis
- tyrosine kinase
- patient reported
- study protocol