Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids.

Masataka ShimonosonoMasaki MorimotoWataru HiroseYasuto TomitaNorihiro MatsuuraSamuel P FlashnerMesra S EbadiEmilea H OkayasuChristian Y LeeWilliam R BrittonCecilia MartinBeverly R WuertzAnuraag S ParikhUma M SachdevaFrank G OndreyVenkatram R AtigaddaCraig A ElmetsJulian A AbramsAmanda B MuirAndres J Klein-SzantoKenneth I WeinbergFatemeh Momen-HeraviHiroshi Nakagawa

Published in: bioRxiv : the preprint server for biology (2024)

HOME0 allows modeling of the homeostatic differentiation gradient and perturbation of the human esophageal epithelium while permitting a comparison of organoids from mice and other organs grown in ADF-based media.

Keyphrases

induced pluripotent stem cells
endothelial cells
pluripotent stem cells
healthcare
type diabetes
adipose tissue
metabolic syndrome
high fat diet induced
insulin resistance