The Impact of Infused Autograft Absolute Numbers of Immune Effector Cells on Survival Post-Autologous Stem Cell Transplantation.
Luis F PorrataPublished in: Cells (2022)
Autologous stem cell transplantation treatment has been viewed as a therapeutic modality to enable the infusion of higher doses of chemotherapy to eradicate tumor cells. Nevertheless, recent reports have shown that, in addition to stem cells, infusion of autograft immune effector cells produces an autologous graft-versus-tumor effect, similar to the graft-versus-tumor effect observed in allogeneic-stem cell transplantation, but without the clinical complications of graft-versus-host disease. In this review, I assess the impact on clinical outcomes following infusions of autograft-antigen presenting cells, autograft innate and adaptive immune effector cells, and autograft immunosuppressive cells during autologous stem cell transplantation. This article is intended to provide a platform to change the current paradigmatic view of autologous stem cell transplantation, from a high-dose chemotherapy-based treatment to an adoptive immunotherapeutic intervention.
Keyphrases
- stem cell transplantation
- high dose
- induced apoptosis
- low dose
- cell cycle arrest
- stem cells
- cell therapy
- bone marrow
- randomized controlled trial
- endoplasmic reticulum stress
- emergency department
- squamous cell carcinoma
- regulatory t cells
- dendritic cells
- risk factors
- case report
- locally advanced
- radiation therapy
- smoking cessation
- single cell