Differentiation of human primary testicular cells in the presence of SCF using the organoid culture system.

Aghbibi NikmahzarMorteza KorujiMehrdad JahanshahiFarnaz KhadiviMaryam ShabaniSanaz DehghaniMehdi ForouzeshAyob JabariNarjes FeizollahiMaryam SalemNasrin Ghanami GashtiYasaman AbbasiMehdi Abbasi

Published in: Artificial organs (2023)

Our findings revealed that the testicular organoid culture system promote the spermatogonial stem cell (SSC) differentiation, especially in presence of SCF. Developed organoids are capable of recapitulating many important properties of a stem cell niche.

Keyphrases

stem cells
induced apoptosis
germ cell
induced pluripotent stem cells
endothelial cells
cell cycle arrest
cell therapy
single cell
endoplasmic reticulum stress
pluripotent stem cells
signaling pathway
cell death
oxidative stress
bone marrow