An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases.
Jérôme RobertNicholas L WeilingerLi-Ping CaoStefano CataldiEmily B ButtonSophie StukasEmma M MartinPhilip SeiblerMegan GilmourTara M CaffreyElyn M RoweJianjia FanBrian MacVicarMatthew J FarrerCheryl L WellingtonPublished in: Molecular neurodegeneration (2020)
This model is a suitable research tool to investigate arterial NVU functions in healthy and disease states. Further, the design of the platform allows culture under native-like flow conditions for extended periods of time and yields sufficient tissue and media for downstream immunohistochemistry and biochemistry analyses.